pLP2載體說明書

Zeocin™ belongs to a family of structurally related bleomycin/phleomycin-type 

antibiotics isolated from Streptomyces. Antibiotics in this family are broad 

spectrum antibiotics that act as strong antibacterial and antitumor drugs. They 

show strong toxicity against bacteria, fungi （including yeast）, plants, and 

mammalian cells （Baron et al., 1992; Drocourt et al., 1990; Mulsant et al., 1988; 

Perez et al., 1989）. 

The Zeocin™ resistance protein has been isolated and characterized （Calmels et 

al., 1991; Drocourt et al., 1990）. This protein, the product of the Sh ble gene 

（Streptoalloteichus hindustanus bleomycin gene）, is a 13.7 kDa protein that binds 

Zeocin™ and inhibits its DNA strand cleavage activity. Expression of this protein 

in eukaryotic and prokaryotic hosts confers resistance to Zeocin™.

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