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Mediomics公司于2001年創立于美國密蘇里州，Mediomics已通過ISO 9001: 2015認證并致力于為科研機構、即時檢測、醫藥企業以及醫療和環境研究市場提供創新的檢測試劑盒和生物傳感器等產品，其檢測試劑盒可以簡單快速的定量檢測生物學和臨床相關的大分子物質，包括DNA、生物標志物、激素、抗體、細胞內信號分子、蛋白質復合物、細菌、真菌和病毒等。
Mediomics代理——上海起發
Mediomics目前擁有四個核心專有技術：
1. Bridge-It：一種快速靈敏的DNA-蛋白質結合物檢測平臺。
Bridge-It系列試劑盒可用來檢測DNA結合蛋白及其配體，和共調節因子。該系列試劑盒基于一個簡單的實驗原理：一段針對已知蛋白的具有序列特異DNA結合位點的DNA雙鏈被分為兩段，每段含有一個短的單鏈突出端。這些突出端很短，因此沒有靶蛋白時他們不會自發的重新結合。當靶蛋白出現時，靶蛋白與完整的DNA序列結合位點的高親和力使得兩段DNA雙鏈重新結合。通過在每段位點加入適當的熒光探針就可以檢測到該結合。然后用熒光共振能量轉移技術（fluorescence resonance energy transfer，FRET）檢測熒光信號的變化來判斷DNA結合蛋白或其配體。
該系列試劑盒具有以下特色：
1)簡單的混合和測試方法：只需要混合樣本和反應試劑，不需要其他操作技術。直接檢測樣本無需稀釋步驟，只需混合樣本/標準品和反應試劑。2)快速：孵育30min后即可檢測熒光信號。3)定量檢測。4)可重復性好：實驗變異性小，避免了抗體或放射性探針帶來的批次間的差異。5)可實現高通量篩選。
2. PINCER：一種快速的生物傳感器、生物測定和生物芯片平臺。
PINCER Assays是一種用于定量檢測生物樣本中的生物標志物、細胞和病原體濃度的技術。該系列產品分為FRET-PINCER Assay和TRF-PINCER Assay兩種，分別使用熒光共振能量轉移技術（fluorescence resonance energy transfer，FRET）和時間分辨熒光（Time-Resolved Fluorometry，TRF）方法檢測。其檢測原理是：帶有熒光探針的抗體由一個靈活的連接物通過互補的單鏈DNA突出端與DNA雙鏈化學結合，這些突出端使得兩個DN**段有結合的可能性，然而在沒有靶蛋白的情況下，兩個DNA片段結合的可能性極小。當存在靶蛋白時，與PINCER試劑結合的靶蛋白將促使互補DNA單鏈突出端的結合而形成雙鏈DNA。這種緊密穩定的結合使熒光團聚合起來，發生熒光共振能量轉移。因此，檢測樣本發出的熒光能量水平或亮度的變化即可定量靶蛋白的濃度。
PINCER Assay系列試劑盒的特色：
1)簡便：混合樣本/標準品與分析試劑在室溫孵育。
2)快速：孵育30min后檢測熒光信號。
3)檢測范圍廣：直接檢測樣本，無需稀釋步驟。
4)兼容性：與大多數熒光讀數儀兼容。
5)可實現高通量篩選。
3、使用創新技術篩選和研發可用于科研、臨床診斷和治療的新型高親和力捕獲試劑。
4、抗血管生成相關療法。
這些技術已被證實適于檢測一系列關鍵大分子物質，包括cAMP、色氨酸、S-腺苷蛋氨酸、磷酸二酯酶、生物素、胰島素、C肽、白蛋白、C反應蛋白、IgG、IgM和大腸桿菌等等。
Mediomics相關產品
| Product | Catalog Number | Kit components |
| Bridge-It Assay Kits | ||
| Bridge-It cAMP 384 | 122938 | 10uM cAMP stock standard in H2O, 2X Assay Solution A, 10X Lysis Buffer, Buffer B |
| Bridge-It cAMP 100 | 122939 | 10uM cAMP stock standard in H2O, 2X Assay Solution A, 10X Lysis Buffer, Buffer B |
| Bridge-It cAMP 96 | 122935 | 10uM cAMP stock standard in H2O, Assay Solution A, 10X Lysis Buffer, Buffer B, 10X KRB-IBMX Buffer |
| Bridge-It cAMP 50 | 122934 | 10uM cAMP stock standard in H2O, Assay Solution A, 10X Lysis Buffer, Buffer B, 10X KRB-IBMX Buffer |
| Bridge-It cAMP-PDE 384 | PD1007-384 | 10uM cAMP stock standard, 2X Assay Solution, Stop Solution, 10X PDE Reaction Buffer, Buffer B |
| Bridge-It cAMP-PDE 100 | PD1007-100 | 10uM cAMP stock standard, 2X Assay Solution, Stop Solution, 10X PDE Reaction Buffer, Buffer B |
| Bridge-It cAMP-PDE 96 | PD1016-96 | 10uM cAMP stock standard, 2X Assay Solution, Stop Solution, 10X PDE Reaction Buffer, Buffer B |
| Bridge-It cAMP-PDE 60 | PD1016-60 | 10uM cAMP stock standard, 2X Assay Solution, Stop Solution, 10X PDE Reaction Buffer, Buffer B |
| Bridge-It SAM 384 | 1-1-1004B | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| Bridge-It SAM 100 | 1-1-1004A | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| Bridge-It SAM 96 | 1-1-1003B | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| Bridge-It SAM 50 | 1-1-1003A | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| Bridge-It L-MET 384 | 1-1-1006B | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| Bridge-It L-MET 100 | 1-1-1006A | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| Bridge-It L-MET 96 | 1-1-1005B | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| Bridge-It L-MET 50 | 1-1-1005A | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| Bridge-It L-Tryptophan 384 | 1-1-1002B | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| Bridge-It L-Tryptophan 100 | 1-1-1002A | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| Bridge-It L-Tryptophan 96 | 1-1-1001B | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| Bridge-It L-Tryptophan 50 | 1-1-1001A | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| TR-FRET Bridge-It Assay Kits | ||
| TR-FRET Bridge-It® L-Tryptophan 100 | TRF-1-1-1002A | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| TR-FRET Bridge-It® L-Tryptophan 384 | TRF-1-1-1002B | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| TR-FRET Bridge-It® L-Tryptophan 50 | TRF-1-1-1001A | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| TR-FRET Bridge-It® L-Tryptophan 96 | TRF-1-1-1001B | 1 mM L-tryptophan standard in H20, L-Tryptophan Assay Solution A, Buffer W, Buffer C |
| TR-FRET Bridge-It® SAM 100 | TRF-1-1-1004A | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| TR-FRET Bridge-It® SAM 384 | TRF-1-1-1004B | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| TR-FRET Bridge-It® SAM 50 | TRF-1-1-1003A | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| TR-FRET Bridge-It® SAM 96 | TRF-1-1-1003B | 10 mM S-adenosyl methionine standard in 10mM 2-mercaptoethanol, SAM Assay Solution, Buffer S, Buffer CM |
| TR-FRET Bridge-It® L-MET 50 | TRF-1-1-1005A | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| TR-FRET Bridge-It® L-MET 96 | TRF-1-1-1005B | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| TR-FRET Bridge-It® L-MET 100 | TRF-1-1-1006A | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| TR-FRET Bridge-It® L-MET 384 | TRF-1-1-1006B | L-Methionine Standard (3.2 mM), Enzyme Solution L, Buffer L, SAM Assay Solution |
| FRET-PINCER Assay Kits | ||
| hAlbumin FRET 384 | AH1005-384 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hAlbumin FRET 100 | AH1005-100 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hAlbumin FRET 50 | AH1005-50 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hAlbumin FRET 96 | AH1005-96 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP FRET 384 | CH1008-384 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP FRET 100 | CH1008-100 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP FRET 96 | CH1021-96 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP FRET 50 | CH1021-50 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin FRET 384 | IH1010-384 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin FRET 100 | IH1010-100 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin FRET 50 | IH1017-50 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin FRET 96 | IH1017-96 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| Mouse IgM FRET 384 | IM1009-384 | Mouse IgM standard (2 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| Mouse IgM FRET 100 | IM1009-100 | Mouse IgM standard (2 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| Mouse IgG FRET 384 | MIG1012-384 | Mouse IgG standard (2 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| Mouse IgG FRET 100 | MIG1012-100 | Mouse IgG standard (2 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| rIgG FRET 96 | RI1024-96 | Rabbit IgG standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| rIgG FRET 50 | RI1024-50 | Rabbit IgG standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| rIgG FRET 384 | RI1015-384 | Rabbit IgG standard (2 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| rIgG FRET 100 | RI1015-100 | Rabbit IgG standard (2 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| TRF-PINCER Assay Kits | ||
| Biotin TRF 384 | BTTR-1006-384 | Biotin standard (2 uM), PINCER A, PINCER B, Assay Solution C, Buffer M |
| Biotin TRF 100 | BTTR-1006-100 | Biotin standard (2 uM), PINCER A, PINCER B, Assay Solution C, Buffer M |
| hAlbumin TRF 384 | AHTR1005-384 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hAlbumin TRF 100 | AHTR1005-100 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hAlbumin TRF 50 | AHTR1005-50 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hAlbumin TRF 96 | AHTR1005-96 | Human albumin standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP TRF 50 | CHTR1021-50 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP TRF 96 | CHTR1021-96 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP TRF 100 | CHTR1008-100 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hCRP TRF 384 | CHTR1008-384 | hCRP standard (1.6 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hIgG TRF 384 | HITR1011-384 | hIgG standard (40 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hIgG TRF 100 | HITR1011-100 | hIgG standard (40 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin TRF 384 | IHTR1010-384 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin TRF 100 | IHTR1010-100 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin TRF 50 | IHTR1017-50 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| hInsulin TRF 96 | IHTR1017-96 | Insulin standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| mIgG TRF 384 | MIGTR1012-384 | Mouse IgG standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| mIgG TRF 200 | MIGTR1012-200 | Mouse IgG standard (8 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| mIgG TRF 96 | MIGTR1020-96 | Mouse IgG standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| mIgG TRF 50 | MIGTR1020-50 | Mouse IgG standard (5.12 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| mIgM TRF 384 | IMTR1009-384 | Mouse IgM standard (80 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| mIgM TRF 200 | IMTR1009-200 | Mouse IgM standard (80 ug/ml), PINCER A, PINCER B, Buffer C, Buffer M |
| Other Products | ||
| Recombinant human methionine aminopeptidase-2 | PM-803262-100 µg | Each vial contains 200 µl (~100 µg) of purified human methionine aminopeptidase-2 in 20 mM Hepes, pH 7.4, 0.15 M NaCl, 0.02% NaN3, 10% glycerol and 0.1 mM Co(II) |
| Anti-recombinant human MetAP-2 (full-length) Polyclonal Antibody | PAB-503208 | Each vial contains 120 µl of anti-rhMetAP2 IgG (0.85 mg/ml) in TBS with 0.02% NaN3 |
| Anti-hMetAP-2 (C-terminal) Polyclonal Antibody | PAB-503209 | Each vial contains 100 µl of anti-hMetAP2 IgG in PBS |
| 10X KRB-IBMX Buffer | 122937 | 10X KRB-IBMX Buffer solution is a mixture of a 10X concentrate of Krebs-Ringer Bicarbonate Buffer (KRB) supplemented with a 10X concentration (i.e., 7.5 mM) of 3-Isobutyl-1-Methylxanthine (IBMX) and containing 10% ethanol (for use in cAMP Assays, order with cAMP assay kits) |
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